FontNuke can be used to remove corrupt font cache files. This application was created by me as a tool for personal use at work. It has been very useful to me. To allow non-admin users to delete font cache files without my involvement. huge Intelligent application quitting and a guaranteed reboot make my life much easier. FontNuke can remove system font caches, Adobe font caches (*.lst), Microsoft Office font caches, and now all QuarkXPress font caches files. It's also free.
I recently added an option that purges spotlight indexes on startup volumes from /.Spotlight.V100. This was necessary due to intermittent unresponsiveness in searching network volumes for some MCX clients. This feature should be used with caution. For more information, please visit FontNuke's homepage.
Version 1.2.11: