FontNuke can be used to remove corrupt font cache files. This application was created by me as a tool for personal use at work. It has been very useful to me. To allow non-admin users to delete font cache files without my involvement. huge Intelligent application quitting and a guaranteed reboot make my life much easier. FontNuke can remove system font caches, Adobe font caches (*.lst), Microsoft Office font caches, and now all QuarkXPress font caches files. It's also free.
I recently added an option that purges spotlight indexes on startup volumes from /.Spotlight.V100. This was necessary due to intermittent unresponsiveness in searching network volumes for some MCX clients. This feature should be used with caution. For more information, please visit FontNuke's homepage.